Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.

PLoS pathogens - 1 Mar 2013

van der Werf Nienke, Redpath Stephen A, Azuma Miyuki, Yagita Hideo, Taylor Matthew D

Abstract excerpt

The suppression of protective Type 2 immunity is a principal factor driving the chronicity of helminth infections, and has been attributed to a range of Th2 cell-extrinsic immune-regulators. However, the intrinsic fate of parasite-specific Th2 cells within a chronic immune down-regulatory environment, and the resultant impact such fate changes may have on host resistance is unknown. We used IL-4gfp reporter mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Disease Susceptibility
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Lymphocyte Activation

Share to Programmed Cell Death 1 Receptor

Share to T-Lymphocytes, Regulatory

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 23516361
DOI: 10.1371/journal.ppat.1003215
PMCID: PMC3597521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.PMID 23516361Read ↗

Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen.Semantic proximity Read ↗

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective responseSemantic proximity Read ↗

Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103− Dendritic CellsSemantic proximity Read ↗

T follicular helper cells differentiate from Th2 cells in response to helminth antigensSemantic proximity Read ↗

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infectionSemantic proximity Read ↗

Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode InfectionSemantic proximity Read ↗

Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite.Semantic proximity Read ↗

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo.Semantic proximity Read ↗

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.Semantic proximity Read ↗

T-cell regulation in helminth parasite infections: implications for inflammatory diseases.Semantic proximity Read ↗

IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infectionSemantic proximity Read ↗

The phenotype and function of naturally existing regulatory dendritic cells in nematode-infected mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.