Article
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.
Molecular and cellular biology - 1 Mar 1993
Gilks C B, Bear S E, Grimes H L, Tsichlis P N
Abstract excerpt
During progression of Moloney murine leukemia virus (Mo-MuLV)-induced rat T cell lymphomas, growth selection results in the expansion of cell clones carrying increasing numbers of integrated proviruses. These new provirus insertions reproducibly contribute to enhanced growth, allowing the emergen...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- DNA Probes
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Interleukin-2
- Lymphoma, T-Cell