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Article

Rab35 mediates transport of Cdc42 and Rac1 to the plasma membrane during phagocytosis.

Molecular and cellular biology - 1 Mar 2010

Shim Jaewon, Lee Sun-Min, Lee Myeong Sup, Yoon Joonsun, Kweon Hee-Seok, Kim Young-Joon

Abstract excerpt

Phagocytosis of invading microbes requires dynamic rearrangement of the plasma membrane and its associated cytoskeletal actin network. The polarization of Cdc42 and Rac1 Rho GTPases to the site of plasma membrane protrusion is responsible for the remodeling of actin structures. However, the mechanism of Rho GTPase recruitment to these sites and the identities of accessory molecules involved in this process are...

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Identifiers

PMID: 20065041
DOI: 10.1128/MCB.01463-09
PMCID: PMC2832496

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