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Article

Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.

Journal of cell science - 1 Mar 2004

Wells Claire M, Walmsley Marita, Ooi Steen, Tybulewicz Victor, Ridley Anne J

Abstract excerpt

Rac GTPases are activated by extracellular stimuli and contribute to cellular responses including cytoskeletal changes and cell migration. Dominant-negative Rac1 has been used to implicate Rac GTPases in these responses, but which of the three mammalian Rac isoforms it inhibits is not known. We s...

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Source

Identifiers

PMID: 14996945
DOI: 10.1242/jcs.00997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14996945-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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