Article

Rac GTPases in Human Diseases

2010-01-01

Abstract excerpt

Rho GTPases are members of the Ras superfamily of GTPases that regulate a wide variety of cellular functions. While Rho GTPase pathways have been implicated in various pathological conditions in humans, to date coding mutations in only the hematopoietic specific GTPase, RAC2 , have been found to cause a human disease, a severe phagocytic immunodeficiency characterized by life-threatening infections in infancy. Int...

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Literature Corpus work: 93a4f8b6-e2fa-5daf-803a-a5b7d9c980b6
DOI: 10.1155/2010/380291

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