Article
Fc receptor-mediated phagocytosis requires CDC42 and Rac1.
The EMBO journal - 2 Nov 1998
Massol P, Montcourrier P, Guillemot J C, Chavrier P
Abstract excerpt
At the surface of phagocytes, antibody-opsonized particles are recognized by surface receptors for the Fc portion of immunoglobulins (FcRs) that mediate their capture by an actin-driven process called phagocytosis which is poorly defined. We have analyzed the function of the Rho proteins Rac1 and...
Topics
- Animals
- Arsenicals
- Bacterial Proteins
- Bacterial Toxins
- Cell Cycle Proteins
- GTP-Binding Proteins
- Leukemia, Basophilic, Acute
- Microscopy, Electron
- Microscopy, Fluorescence
- Mutation
- Phagocytosis
- Phosphoproteins
- Phosphotyrosine
- Protein Tyrosine Phosphatases
- Rats
- Receptors, Fc
- Transfection
- Tumor Cells, Cultured