Article
Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
European journal of neurology - 1 Jul 2008
Pchelina S N, Yakimovskii A F, Emelyanov A K, Ivanova O N, Schwarzman A L, Singleton A B
Abstract excerpt
BACKGROUND AND PURPOSE: Mutations in LRRK2, encoding leucine-rich repeat kinase 2 (or Dardarin), cause autosomal dominant Parkinson's disease (AdPD) and are also found in sporadic PD (sPD). To investigate the frequency of LRRK2 mutations in a sample of Russian PD patients. METHODS: We sequenced the complete coding region of LRRK2 in 65 patients with AdPD and in 30 patients with sPD. Furthermore, in 20 patients...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.