Article
Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
European journal of neurology - 1 Jul 2008
Pchelina S N, Yakimovskii A F, Emelyanov A K, Ivanova O N, Schwarzman A L, Singleton A B
Abstract excerpt
BACKGROUND AND PURPOSE: Mutations in LRRK2, encoding leucine-rich repeat kinase 2 (or Dardarin), cause autosomal dominant Parkinson's disease (AdPD) and are also found in sporadic PD (sPD). To investigate the frequency of LRRK2 mutations in a sample of Russian PD patients. METHODS: We sequenced the complete coding region of LRRK2 in 65 patients with AdPD and in 30 patients with sPD. Furthermore, in 20 patients...
Topics
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease