Article
The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases.
Neuroscience letters - 9 Dec 2005
Hernandez Dena, Paisan Ruiz Coro, Crawley Anthony, Malkani Roneil, Werner John, Gwinn-Hardy Katrina, Dickson Dennis, Wavrant Devrieze Fabienne, Hardy John, Singleton Andrew
Abstract excerpt
Mutations in the leucine-rich kinase 2 gene (LRRK 2) encoding dardarin, on chromosome 12, are a common cause of familial and sporadic Parkinson's disease. The most common mutation, a heterozygous 6055 G>A transition (G 2019 S) accounts for approximately 3--10% of familial Parkinson's disease and 1--8% sporadic Parkinson's disease in several European-derived populations. Some families with disease caused by LRRK 2...
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