Article
G2019S LRRK2 mutation in French and North African families with Parkinson's disease.
Annals of neurology - 1 Nov 2005
Lesage Suzanne, Ibanez Pablo, Lohmann Ebba, Pollak Pierre, Tison François, Tazir Myriem, Leutenegger Anne-Louise, Guimaraes Joao, Bonnet Anne-Marie, Agid Yves, Dürr Alexandra, Brice Alexis
Abstract excerpt
Mutations in LRRK2 were recently identified in autosomal dominant Parkinson's disease (PD), including the G2019S mutation. To evaluate its frequency, we analyzed 198 probands with autosomal dominant PD, mostly from France and North Africa. Surprisingly, the frequency in North African families (7/17, 41%) was greater than those from Europe (5/174, 2.9%). The clinical features in 21 patients, including 1 with a...
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