Article
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2005
Bras Jose Miguel, Guerreiro Rita Joao, Ribeiro Maria Helena, Januario Cristina, Morgadinho Ana, Oliveira Catarina Resende, Cunha Luis, Hardy John, Singleton Andrew
Abstract excerpt
LRRK2 mutations have recently been described in families with Parkinson's disease. Here we show that one of them (G2019S) is present in 6% (7 of 124) unrelated cases of disease in a clinic-based sample series from central Portugal, but not present in 126 controls from the same population. Thus, LRRK2 mutations appear to be a common cause of typical Parkinson's disease and as such will alter clinical practice.
Topics
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- DNA Mutational Analysis
- Family Health
- Female
- Genetic Predisposition to Disease
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged