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Article

Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression.

Cancer letters - 28 Oct 2006

Ju Hyoungseok, Cho Hyunmi, Kim Yong Sung, Kim Woo Ho, Ihm Chunhwa, Noh Seung-Moo, Kim Jin-Bok, Hahn Dong-Soo, Choi Bo-Yuol, Kang Changwon

Abstract excerpt

Overexpression or amplification of the aurora kinase A (AURKA) gene induces chromosomal instability and transformation. AURKA SNPs are associated with several human cancers but their association with gastric cancer has yet to be investigated. In this study, 501 gastric cancer patients and 427 controls were genotyped for two coding SNPs in AURKA, 91A>T (31Ile>Phe) and 169G>A (57Val>Ile). Allele or genotype...

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Source

Identifiers

PMID: 16412566
DOI: 10.1016/j.canlet.2005.11.015

Genes

AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression.PMID 16412566Read ↗

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Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.Semantic proximity Read ↗

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Aurora kinase A in gastrointestinal cancers: time to targetSemantic proximity Read ↗

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Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.Semantic proximity Read ↗

The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics.Semantic proximity Read ↗

Aurora kinases A and B and familial breast cancer risk.Semantic proximity Read ↗

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