Article
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
The EMBO journal - 29 Nov 2006
Engel Matthias, Hindie Valerie, Lopez-Garcia Laura A, Stroba Adriana, Schaeffer Francis, Adrian Iris, Imig Jochen, Idrissova Leila, Nastainczyk Wolfgang, Zeuzem Stefan, Alzari Pedro M, Hartmann Rolf W, Piiper Albrecht, Biondi Ricardo M
Abstract excerpt
Organisms rely heavily on protein phosphorylation to transduce intracellular signals. The phosphorylation of a protein often induces conformational changes, which are responsible for triggering downstream cellular events. Protein kinases are themselves frequently regulated by phosphorylation. Recently, we and others proposed the molecular mechanism by which phosphorylation at a hydrophobic motif (HM) regulates...
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