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Article

Allosteric activation of apicomplexan calcium-dependent protein kinases.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015

Ingram Jessica R, Knockenhauer Kevin E, Markus Benedikt M, Mandelbaum Joseph, Ramek Alexander, Shan Yibing, Shaw David E, Schwartz Thomas U, Ploegh Hidde L, Lourido Sebastian

Abstract excerpt

Calcium-dependent protein kinases (CDPKs) comprise the major group of Ca2+-regulated kinases in plants and protists. It has long been assumed that CDPKs are activated, like other Ca2+-regulated kinases, by derepression of the kinase domain (KD). However, we found that removal of the autoinhibitory domain from Toxoplasma gondii CDPK1 is not sufficient for kinase activation. From a library of heavy chain-only...

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Identifiers

PMID: 26305940
DOI: 10.1073/pnas.1505914112
PMCID: PMC4568647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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