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Modulating Phosphorylation by Proximity-Inducing Modalities for Cancer Therapy

9 Dec 2024

Abstract excerpt

Abnormal phosphorylation of proteins can lead to various diseases, particularly cancer. Therefore, the development of small molecules for precise regulation of protein phosphorylation holds great potential for drug design. While the traditional kinase/phosphatase small-molecule modulators have shown some success, achieving precise phosphorylation regulation has proven to be challenging. The emergence of...

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PMID: 39648992
DOI: 10.1021/acs.jmedchem.4c02624

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