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Article

Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach.

PloS one - 1 Jan 2021

Shafie Alaa, Khan Shama, Batra Sagar, Anjum Farah, Mohammad Taj, Alam Shoaib, Yadav Dharmendra Kumar, Islam Asimul, Hassan Md Imtaiyaz

Abstract excerpt

PIM1, is a serine/threonine proto-oncogene kinase, involved in many biological functions, including cell survival, proliferation, and differentiation, thus play a key role in oncogenesis. It plays a crucial role in the onset and progression of various hematopoietic and non-hematopoietic malignancies, including acute myeloid leukemia and prostate cancer. Mutations in PIM1, especially in its kinase domain, can...

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Identifiers

PMID: 34679086
DOI: 10.1371/journal.pone.0258929
PMCID: PMC8535467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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