Article

Identification of Kinase inhibitors as PINK1 activators for the treatment of Parkinson’s Disease

2023-04-06

Abstract excerpt

Mutations in PINK1 kinase are known to be responsible for the early-onset of Parkinson's disease. The protein resides on the outer-membrane of healthy mitochondria, and acts as a quality controller by regulating and maintaining dysfunctional mitochondria also known as mitophagy. Limited knowledge of the mechanism of protein has made it cumbersome to elucidate an effective treatment. In this paper, we screen a set...

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Literature Corpus work: 167e525c-ea36-53cc-853e-1f8261646553
DOI: 10.21203/rs.3.rs-2754116/v1

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