Article

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

2023-04-26

Abstract excerpt

Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is gaining momentum, a pharmacological tool to distinguish the mammalian isozymes is still lacking. Here, we implemented an analog-sensitive approach for IP6Ks and performed a high-throug...

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Identifiers and source

Literature Corpus work: 858604d9-79d7-55df-a529-696a8e90a632
DOI: 10.1101/2023.04.26.538378

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