Article

Identification and structural characterization of small-molecule inhibitors of PINK1

2023-10-02

Abstract excerpt

Mutations in PTEN-induced putative kinase 1 (PINK1) cause early-onset autosomal recessive Parkinson’s Disease (PD). PINK1 is a Ser/Thr protein kinase which functions as a mitochondrial damage sensor and initiates mitochondrial quality control by accumulating on the damaged organelle. There, it will autophosphorylate and then phosphorylate ubiquitin chains, which in turn will recruit and activate Parkin, and E3 ubi...

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Literature Corpus work: 03975e88-622d-586e-ab00-b520a259f077
DOI: 10.1101/2023.10.02.560389

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