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Article

Extended Impact of Pin1 Catalytic Loop Phosphorylation Revealed by S71E Phosphomimetic.

Journal of molecular biology - 2 Mar 2018

Mahoney Brendan J, Zhang Meiling, Zintsmaster John S, Peng Jeffrey W

Abstract excerpt

Pin1 is a two-domain human protein that catalyzes the cis-trans isomerization of phospho-Ser/Thr-Pro (pS/T-P) motifs in numerous cell-cycle regulatory proteins. These pS/T-P motifs bind to Pin1's peptidyl-prolyl isomerase (PPIase) domain in a catalytic pocket, between an extended catalytic loop and the PPIase domain core. Previous studies showed that post-translational phosphorylation of S71 in the catalytic loop...

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Identifiers

PMID: 29317221
DOI: 10.1016/j.jmb.2017.12.021

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Extended Impact of Pin1 Catalytic Loop Phosphorylation Revealed by S71E Phosphomimetic.PMID 29317221Read ↗

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