Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of the warfarin-resistance polymorphism, VKORC1 Asp36Tyr, and its effect on dosage algorithms in a genetically heterogeneous anticoagulant clinic.

Clinical biochemistry - 1 Apr 2012

Shuen Andrew Y, Wong Betty Y L, Fu Lei, Selby Rita, Cole David E C

Abstract excerpt

OBJECTIVES: To assess allele frequency and potential predictive value of recurrent polymorphisms affecting warfarin metabolism in an unselected patient cohort attending an anticoagulant clinic (n=186). DESIGN AND METHODS: Genotyping of ten SNPs in five candidate genes (VKORC1, CYP2C9, CALU, EPHX and GGCX) was carried out by ABI PRISM SNaPshot multiplex method. RESULTS: We confirm the association between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Drug Dosage Calculations

Share to Mixed Function Oxygenases

Share to Regression Analysis

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 22266406
DOI: 10.1016/j.clinbiochem.2012.01.002

Genes

VKORC1
CALU
GGCX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the warfarin-resistance polymorphism, VKORC1 Asp36Tyr, and its effect on dosage algorithms in a genetically heterogeneous anticoagulant clinic.PMID 22266406Read ↗

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.Semantic proximity Read ↗

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistanceSemantic proximity Read ↗

Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.Semantic proximity Read ↗

A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk.Semantic proximity Read ↗

Polymorphisms in VKORC1 have more impact than CYP2C9 polymorphisms on early warfarin International Normalized Ratio control and bleeding rates.Semantic proximity Read ↗

The influence of VKORC1 and CYP2C9 gene sequence variants on the stability of maintenance phase warfarin treatment.Semantic proximity Read ↗

Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX.Semantic proximity Read ↗

A new warfarin dosing algorithm including VKORC1 3730 G > A polymorphism: comparison with results obtained by other published algorithms.Semantic proximity Read ↗

Frequency of VKORC1 (C1173T) and CYP2C9 genetic polymorphisms in Egyptians and their influence on warfarin maintenance dose: proposal for a new dosing regimen.Semantic proximity Read ↗

Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin.Semantic proximity Read ↗

A multiplex assay for detecting genetic variations in CYP2C9, VKORC1, and GGCX involved in warfarin metabolism.Semantic proximity Read ↗

The c.-1639G>A polymorphism of the VKORC1 gene in Serbian population: retrospective study of the variability in response to oral anticoagulant therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.