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Article

The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort.

Scientific reports - 15 Jul 2020

Al Ammari Maha, AlBalwi Mohammed, Sultana Khizra, Alabdulkareem Ibrahim B, Almuzzaini Bader, Almakhlafi Nada S, Aldrees Mohammed, Alghamdi Jahad

Abstract excerpt

Warfarin is a frequently prescribed oral anticoagulant with a narrow therapeutic index, requiring careful dosing and monitoring. However, patients respond with significant inter-individual variability in terms of the dose and responsiveness of warfarin, attributed to genetic polymorphisms within the genes responsible for the pharmacokinetics and pharmacodynamics of warfarin. Extensive warfarin pharmacogenetic...

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Identifiers

PMID: 32669629
DOI: 10.1038/s41598-020-68519-9
PMCID: PMC7363835

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