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Article

The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations.

Journal of applied genetics - 1 May 2014

Sominsky Sophia, Korostishevsky Michael, Kurnik Daniel, Aklillu Eleni, Cohen Yoram, Ken-Dror Gie, Loebstein Ronen, Halkin Hillel, Gak Eva

Abstract excerpt

The vitamin K epoxide reductase (VKORC1) is a key enzyme in the vitamin K cycle impacting various biological processes. VKORC1 genetic variability has been extensively studied in the context of warfarin pharmacogenetics revealing different distributions of VKORC1 haplotypes in various populations. We previously identified the VKORC1 Asp36Tyr mutation that was associated with warfarin resistance and with...

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Source

Identifiers

PMID: 24425227
DOI: 10.1007/s13353-013-0189-2

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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