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Article

Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.

PloS one - 1 Jan 2012

Jorgensen Andrea L, FitzGerald Richard J, Oyee James, Pirmohamed Munir, Williamson Paula R

Abstract excerpt

BACKGROUND: Warfarin is a highly effective anticoagulant however its effectiveness relies on maintaining INR in therapeutic range. Finding the correct dose is difficult due to large inter-individual variability. Two genes, CYP2C9 and VKORC1, have been associated with this variability, leading to genotype-guided dosing tables in warfarin labeling. Nonetheless, it remains unclear how genotypic information should be...

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Identifiers

PMID: 22952875
DOI: 10.1371/journal.pone.0044064
PMCID: PMC3430615

Genes

VKORC1

Provenance

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