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Isolation by fluorescence-activated cell sorting of Chinese hamster ovary cell lines with pleiotropic, temperature-conditional defects in receptor recycling.

The Journal of biological chemistry - 25 Jun 1991

Cain C C, Wilson R B, Murphy R F

Abstract excerpt

We have isolated several Chinese hamster ovary cell lines with temperature-sensitive defects in the recycling of receptors after endocytosis. These cell lines were selected using fluorescence-activated cell sorting for retention of a pulse of labeled transferrin after a chase in the presence of unlabeled transferrin. One of these cell lines, TfT1.11, was selected for further characterization. In TfT1.11 the...

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PMID: 1711039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Isolation by fluorescence-activated cell sorting of Chinese hamster ovary cell lines with pleiotropic, temperature-conditional defects in receptor recycling.PMID 1711039Read ↗

Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment.Semantic proximity Read ↗

The receptor-recycling and lysosome biogenesis mutant TfT1.11 belongs to a new complementation group, End6.Semantic proximity Read ↗

Isolation of three classes of conditional lethal Chinese hamster ovary cell mutants with temperature-dependent defects in low density lipoprotein receptor stability and intracellular membrane transport.Semantic proximity Read ↗

Impaired secretion and fluid-phase endocytosis in the End4 mutant of Chinese hamster ovary cells.Semantic proximity Read ↗

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.Semantic proximity Read ↗

Novel method for isolating mammalian cells defective in fluid-phase endocytosis.Semantic proximity Read ↗

Dynamin-dependent transferrin receptor recycling by endosome-derived clathrin-coated vesicles.Semantic proximity Read ↗

Recovery of function in Chinese hamster ovary cell mutants with temperature-sensitive defects in vacuolar acidification.Semantic proximity Read ↗

The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected.Semantic proximity Read ↗

Isolation of NPC1-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis.Semantic proximity Read ↗

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Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.Semantic proximity Read ↗

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