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Article

Novel method for isolating mammalian cells defective in fluid-phase endocytosis.

Somatic cell and molecular genetics - 1 Nov 1992

Wang R H, Colbaugh P A, Kuo P, Bau M Y, Poppe L M, Draper R K

Abstract excerpt

A new method for isolating mutants defective in fluid-phase endocytosis has been developed based on the observation that endocytosed horseradish peroxidase can be made lethal to cells. The method was used to isolate a mutant from Chinese hamster ovary cells, termed HRP-1, that was temperature-sensitive for viability and had a 70% reduction in the rate of horseradish peroxidase endocytosis at the restrictive...

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PMID: 1287852
DOI: 10.1007/BF01232650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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