Article
DNA repair and cell cycle control genes and the risk of young-onset lung cancer.
Cancer research - 15 Nov 2006
Landi Stefano, Gemignani Federica, Canzian Federico, Gaborieau Valérie, Barale Roberto, Landi Debora, Szeszenia-Dabrowska Neonilia, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Foretova Lenka, Janout Vladimir, Bencko Vladimir, Gioia-Patricola Lydie, Hall Janet, Boffetta Paolo, Hung Rayjean J, Brennan Paul
Abstract excerpt
Exposure to tobacco smoke and to mutagenic xenobiotics can cause various types of DNA damage in lung cells, which, if not corrected by DNA repair systems, may lead to deregulation of the cell cycle and, ultimately, to cancer. Genetic variation could thus be an important factor in determining susceptibility to tobacco-induced lung cancer with genetic susceptibility playing a larger role in young-onset cases...
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