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Article

A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers.

International journal of cancer - 1 Apr 2008

Lee Yuan-Chin Amy, Morgenstern Hal, Greenland Sander, Tashkin Donald P, Papp Jeanette, Sinsheimer Janet, Cao Wei, Hashibe Mia, You Nai-Chieh Y, Mao Jenny T, Cozen Wendy, Mack Thomas M, Zhang Zuo-Feng

Abstract excerpt

Tobacco smoking is a major risk factor for lung and upper-aerodigestive-tract (UADT) cancers. One possible mechanism for the associations may be through DNA damage pathways. DNA Ligase I (LIG1) is a DNA repair gene involved in both the nucleotide excision repair (NER) and the base excision repair (BER) pathways. We examined the association of 4 LIG1 polymorphisms with lung and UADT cancers, and their potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18059021
DOI: 10.1002/ijc.23274
PMCID: PMC2676936

Genes

LIG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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