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The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer.

Anticancer research - 1 Aug 2023

Lee Yen-Hsien, Wang Shou-Cheng, Li Chia-Hsiang, Chen Li-Hsiou, Shen Te-Chun, Liu Yen-Feng, Wang Yun-Chi, Tsai Chia-Wen, Hsia Te-Chun, Bau DA-Tian, Chang Wen-Shin

Abstract excerpt

BACKGROUND/AIM: Impaired non-homologous end-joining DNA repair capacity may have a significant role in maintaining genome integrity and triggering carcinogenesis. However, the specific impact of DNA ligase 4 (Lig4) genotypes remains unclear. This study aimed to assess the contribution of Lig4 genotypes to the risk of developing lung cancer. MATERIALS AND METHODS: Polymerase chain reaction-restriction fragment...

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PMID: 37500161
DOI: 10.21873/anticanres.16520

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