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Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2008

An Yu, Jin Guangfu, Wang Haifeng, Wang Yi, Liu Hongliang, Li Rui, Wang Haijian, Qian Ji, Sun Weiwei, Wang Yi, Ma Hongxia, Miao Ruifeng, Hu Zhibin, Jin Li, Wei Qingyi, Shen Hongbing, Huang Wei, Lu Daru

Abstract excerpt

DNA mismatch repair (MMR) plays an important role in maintaining genome stability. Defects in MMR genes have been involved in several types of sporadic and hereditary cancers. hMLH1 is considered one of central members of the MMR pathway. We conducted a hospital-based case-control study to investigate associations of common variations in the hMLH1 gene and risk of lung cancer. A total of 500 cases and 517...

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Identifiers

PMID: 17870204
DOI: 10.1016/j.lungcan.2007.08.003

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