Article
Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.
Cancer research - 1 Feb 2012
Leng Shuguang, Stidley Christine A, Liu Yushi, Edlund Christopher K, Willink Randall P, Han Younghun, Landi Maria Teresa, Thun Michael, Picchi Maria A, Bruse Shannon E, Crowell Richard E, Van Den Berg David, Caporaso Neil E, Amos Christopher I, Siegfried Jill M, Tesfaigzi Yohannes, Gilliland Frank D, Belinsky Steven A
Abstract excerpt
The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to assess the association between promoter hypermethylation of a 12-gene panel and common variation in...
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