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Article

Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2002

Shen Hongbing, Spitz Margaret R, Qiao Yawei, Zheng Yuxin, Hong Waun K, Wei Qingyi

Abstract excerpt

DNA ligases catalyze the joining of single and double-strand DNA breaks, which is an essential step in DNA replication, recombination and repair. Recently, a common single nucleotide polymorphism (A-->C) in exon 6 of DNA ligase I (LIG1) was identified, but its functional relevance remains to be determined. Because LIG1 participates in DNA repair and reduced DNA repair capacity is associated with risk of lung...

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Identifiers

PMID: 12009232
DOI: 10.1016/s0169-5002(01)00485-8

Genes

LIG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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