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Article

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

Human molecular genetics - 15 Jun 2002

Tiainen Marianne, Vaahtomeri Kari, Ylikorkala Antti, Mäkelä Tomi P

Abstract excerpt

Germline mutations of the LKB1 tumor suppressor gene lead to Peutz-Jeghers syndrome (PJS), with a predisposition to cancer. LKB1 encodes for a nuclear and cytoplasmic serine/threonine kinase, which is inactivated by mutations observed in PJS patients. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G(1) cell cycle arrest. Here we have investigated molecular mechanisms...

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Identifiers

PMID: 12045203
DOI: 10.1093/hmg/11.13.1497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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