Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle.

Development (Cambridge, England) - 1 Dec 2006

Dong Feiyan, Sun Xiaoxia, Liu Wei, Ai Di, Klysik Elizabetha, Lu Mei-Fang, Hadley Julia, Antoni Laurent, Chen Li, Baldini Antonio, Francis-West Pip, Martin James F

Abstract excerpt

Recent experiments, showing that both cranial paraxial and splanchnic mesoderm contribute to branchiomeric muscle and cardiac outflow tract (OFT) myocardium, revealed unexpected complexity in development of these muscle groups. The Pitx2 homeobox gene functions in both cranial paraxial mesoderm, to regulate eye muscle, and in splanchnic mesoderm to regulate OFT development. Here, we investigated Pitx2 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Branchial Region
Share to Chick Embryo

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Homeobox

Share to Homeobox Protein PITX2

Share to Mesoderm

Share to Muscle Development

Share to Myoblasts

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 17107996
DOI: 10.1242/dev.02693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle.PMID 17107996Read ↗

Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch.Semantic proximity Read ↗

Multiple Roles of Pitx2 in Cardiac Development and DiseaseSemantic proximity Read ↗

Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium.Semantic proximity Read ↗

The role of Pitx2 in maintaining the phenotype of myogenic precursor cells in the extraocular muscles.Semantic proximity Read ↗

Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration.Semantic proximity Read ↗

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.Semantic proximity Read ↗

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of masticationSemantic proximity Read ↗

Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesisSemantic proximity Read ↗

Pitx2c modulates cardiac-specific transcription factors networks in differentiating cardiomyocytes from murine embryonic stem cells.Semantic proximity Read ↗

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Semantic proximity Read ↗

Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration.Semantic proximity Read ↗

Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.