Article
Pitx2c modulates cardiac-specific transcription factors networks in differentiating cardiomyocytes from murine embryonic stem cells.
Cells, tissues, organs - 1 Jan 2011
Lozano-Velasco Estefanía, Chinchilla Ana, Martínez-Fernández Sergio, Hernández-Torres Francisco, Navarro Francisco, Lyons Gary E, Franco Diego, Aránega Amelia E
Abstract excerpt
AIM: The knowledge of the molecular signals that control cell differentiation into cardiomyocytes is critical to apply cell-based therapies and repair an injured heart. The transcription factor Pitx2 has essential roles in the development of different organs including the heart. Although a direct role of Pitx2 in the developing myocardium has recently been reported, the molecular pathways driven by Pitx2 as well...
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