Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders.

doi:10.1152/physrev.00044.2008

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Article

Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders.

Physiological reviews - 1 Jul 2009

Iismaa Siiri E, Mearns Bryony M, Lorand Laszlo, Graham Robert M

Abstract excerpt

The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and TG1-7, that catalyze three types of posttranslational modification reactions: transamidation, esterification, and hydrolysis. These reactions are essential for biological processes such as blood coagulation, skin barrier formation,...

Topics

Animals
Autoimmune Diseases
Disease Models, Animal
Genetic Diseases, Inborn
Humans
Inflammation
Mice
Mutation
Neurodegenerative Diseases
Transglutaminases

Source

Open in PubMed

Identifiers

PMID: 19584319
DOI: 10.1152/physrev.00044.2008

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