Article
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Blood - 1 Mar 2004
Rijneveld Anita W, Weijer Sebastiaan, Florquin Sandrine, Esmon Charles T, Meijers Joost C M, Speelman Peter, Reitsma Pieter H, Ten Cate Hugo, van der Poll Tom
Abstract excerpt
The thrombomodulin-protein C-protein S (TM-PC-PS) pathway exerts anticoagulant and anti-inflammatory effects. We investigated the role of TM in the pulmonary immune response in vivo by the use of mice with a mutation in the TM gene (TM(pro/pro)) that was earlier found to result in a minimal capacity for activated PC (APC) generation in the circulation. We here demonstrate that TM(pro/pro) mice also display a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.