Article
Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells.
Thrombosis and haemostasis - 1 Sept 2007
Iakhiaev Alexei V, Rezaie Alireza R, Idell Steven
Abstract excerpt
Pleural mesothelial and vascular endothelial cells express protein C (PC) pathway components including thrombomodulin (TM) and endothelial protein C receptor (EPCR) and activate PC by the thrombin-TM dependent mechanism. We used these cells as model systems to identify molecules involved in endocytosis and degradation of PC. We find that mesothelial and endothelial cells can bind, internalize and degrade PC....
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