Article
The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients.
The international journal of neuropsychopharmacology - 1 Oct 2007
Xing Qinghe, Qian Xueqing, Li Huafang, Wong Shiming, Wu Shengnan, Feng Guoyin, Duan Shiwei, Xu Mingqing, Gao Rui, Qin Wei, Gao Jianjun, Meng Junwei, He Lin
Abstract excerpt
Antipsychotic drugs exert both therapeutic and adverse effects through dopamine D2 receptor (DRD2) antagonism. Genetic variants of this receptor may be responsible for individual variations in neuroleptic response and may therefore be useful in predicting response. In this study we evaluated the role of six polymorphisms of the DRD2 gene in 125 risperidone-treated Chinese schizophrenia patients following the...
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