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Article

D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.

The American journal of psychiatry - 1 Jul 2010

Zhang Jian-Ping, Lencz Todd, Malhotra Anil K

Abstract excerpt

OBJECTIVE: Several lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D(2)) receptor blockade. Therefore, it seems plausible that variation in the DRD(2) gene is associated with clinical response to antipsychotic drug treatment. The authors conducted the first meta-analysis to examine the relationship between DRD2 polymorphisms and antipsychotic drug response. METHOD: A...

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Alleles
Antipsychotic Agents
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Dopamine D2

Treatment Outcome

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Open in PubMed Open full text

Identifiers

PMID: 20194480
DOI: 10.1176/appi.ajp.2009.09040598
PMCID: PMC2896457

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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