DRD1 rs4532 polymorphism: a potential pharmacogenomic marker for treatment response to antipsychotic drugs.

doi:10.1016/j.schres.2012.08.003

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Article

DRD1 rs4532 polymorphism: a potential pharmacogenomic marker for treatment response to antipsychotic drugs.

Schizophrenia research - 1 Dec 2012

Ota Vanessa Kiyomi, Spíndola Letícia Nery, Gadelha Ary, dos Santos Filho Airton Ferreira, Santoro Marcos Leite, Christofolini Denise Maria, Bellucco Fernanda Teixeira, Ribeiro-dos-Santos Ândrea Kely, Santos Sidney, Mari Jair de Jesus, Melaragno Maria Isabel, Bressan Rodrigo Affonseca, Smith Marilia de Arruda Cardoso, Belangero Sintia Iole

Abstract excerpt

We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed 124 patients with schizophrenia, consisting of 59 treatment resistant (TR) and 65 non-TR. We found an association between G-allele and TR schizophrenia (p=0.001; adjusted OR=2.71). Setting the common AA-genotype as reference, the GG-homozygous presented a...

Topics

Adult
Alleles
Antipsychotic Agents
Dose-Response Relationship, Drug
Female
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Outpatients

Pharmacogenetics

Polymorphism, Single Nucleotide

Psychiatric Status Rating Scales

Receptors, Dopamine D1

Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 23036699
DOI: 10.1016/j.schres.2012.08.003

Genes

DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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