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Article

Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function.

The international journal of neuropsychopharmacology - 1 Dec 2004

Lane Hsien-Yuan, Lee Cheng-Chun, Chang Yue-Cune, Lu Chung-Ta, Huang Chiung-Hsien, Chang Wen-Ho

Abstract excerpt

Risperidone is an atypical antipsychotic agent with efficacy for both positive and negative symptoms of schizophrenia. However, what makes an antipsychotic 'atypical' remains unclear. We recently found that the T102C polymorphism in the 5-HT2A receptor gene could affect risperidone's efficacy for negative symptoms. The present study investigated the effect of the Ser311Cys polymorphism in the dopamine D2 receptor...

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Source

Identifiers

PMID: 15140279
DOI: 10.1017/S1461145704004389

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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