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Article

Association of a Schizophrenia Risk Variant at the DRD2 Locus With Antipsychotic Treatment Response in First-Episode Psychosis.

Schizophrenia bulletin - 1 Nov 2015

Zhang Jian-Ping, Robinson Delbert G, Gallego Juan A, John Majnu, Yu Jin, Addington Jean, Tohen Mauricio, Kane John M, Malhotra Anil K, Lencz Todd

Abstract excerpt

Findings from the Psychiatric Genomics Consortium genome-wide association study (GWAS) showed that variation at the DRD2 locus is associated with schizophrenia risk. However, the functional significance of rs2514218, the top DRD2 single nucleotide polymorphism in the GWAS, is unknown. Dopamine D2 receptor binding is a common mechanism of action for all antipsychotic drugs, and DRD2 variants were related to...

Topics

Adolescent
Adult
Antipsychotic Agents
Aripiprazole
Female
Genetic Loci
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Outcome Assessment, Health Care

Polymorphism, Single Nucleotide

Psychotic Disorders

Randomized Controlled Trials as Topic

Receptors, Dopamine D2

Risk

Risperidone

Schizophrenia

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26320194
DOI: 10.1093/schbul/sbv116
PMCID: PMC4601717

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association of a Schizophrenia Risk Variant at the DRD2 Locus With Antipsychotic Treatment Response in First-Episode Psychosis.PMID 26320194Read ↗

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