Article

Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

2019-09-08

Abstract excerpt

Mitochondrial-driven alterations of the epigenome have been reported but whether they are relevant at the organismal level remain unknown. The viable yellow agouti mouse ( A vy ) is a powerful epigenetic biosensor model that reports on the DNA methylation status of the A vy locus through the coat color of the animals. Here we show that maternal exposure to rotenone, a potent mitochondrial complex I inhibitor,...

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Literature Corpus work: 2340edaa-70aa-57ed-801e-9ecd7a310605
DOI: 10.1101/758474

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