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Article

A sustained dietary change increases epigenetic variation in isogenic mice.

PLoS genetics - 1 Apr 2011

Li Cheryl C Y, Cropley Jennifer E, Cowley Mark J, Preiss Thomas, Martin David I K, Suter Catherine M

Abstract excerpt

Epigenetic changes can be induced by adverse environmental exposures, such as nutritional imbalance, but little is known about the nature or extent of these changes. Here we have explored the epigenomic effects of a sustained nutritional change, excess dietary methyl donors, by assessing genomic CpG methylation patterns in isogenic mice exposed for one or six generations. We find stochastic variation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21541011
DOI: 10.1371/journal.pgen.1001380
PMCID: PMC3080854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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