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Article

LRRK2 expression linked to dopamine‐innervated areas

10 Mar 2006

Abstract excerpt

OBJECTIVE: Leucine-rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of LRRK2 in human and rodent brain tissue. METHODS: We analyzed LRRK2 gene activity at the cellular level using in situ hybridization. RESULTS: We found a high and strikingly specific expression of LRRK2 mRNA in rodent striatum and parts of cortex and no signals in dopamine neurons. In human...

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PMID: 16532471
DOI: 10.1002/ana.20808

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