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Article

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.

PloS one - 1 Jan 2014

Dorval Véronique, Mandemakers Wim, Jolivette Francis, Coudert Laetitia, Mazroui Rachid, De Strooper Bart, Hébert Sébastien S

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of genetic Parkinson's disease (PD). The biological function of LRRK2 and how mutations lead to disease remain poorly defined. It has been proposed that LRRK2 could function in gene transcription regulation; however, this issue remains controversial. Here, we investigated in parallel gene and microRNA (miRNA) transcriptome profiles of...

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Identifiers

PMID: 24427314
DOI: 10.1371/journal.pone.0085510
PMCID: PMC3888428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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