Article
The immunodominant CD8+ T cell epitope region of Theiler's virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells.
Virology - 30 Mar 2007
Myoung Jinjong, Hou Wanqiu, Kang Bongsu, Lyman Michael A, Kang Jeong-Ah, Kim Byung S
Abstract excerpt
Theiler's virus infection induces an immune-mediated demyelinating disease, providing a relevant animal model of human multiple sclerosis. VP2(121-130)-specific CD8+ T cells in resistant H-2b mice account for the majority of CNS-infiltrating CD8+ T cells. To further study the role of the CD8(+) T...
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