Article
Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice.
Journal of neuroimmunology - 1 Jun 2001
Palma J P, Lee H G, Mohindru M, Kang B S, Dal Canto M, Miller S D, Kim B S
Abstract excerpt
Theiler's virus induces immune-mediated demyelinating disease similar to human MS in susceptible mice. Though the MHC class II-restricted T cell response is critical, susceptibility/resistance is also associated with a MHC class I haplotype. Here we report that perforin-deficient C57BL/6 mice (pKO) are susceptible to demyelination and develop clinical disease. The levels of primary demyelination, proliferation,...
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