Article
Clearance of Theiler's virus infection depends on the ability to generate a CD8 <sup>+</sup> T cell response against a single immunodominant viral peptide
11 Aug 2003
Abstract excerpt
Theiler's murine encephalomyelitis virus (TMEV) induces a chronic demyelinating disease in the central nervous system of susceptible mice. Resistance to persistent TMEV infection maps to he D locus of the major histocompatibility complex suggesting a prominent role of antiviral CTL in the protective immune response. Introduction of the D(b) gene into the FVB strain confers resistance to this otherwise susceptible...
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