Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.

doi:10.1128/JVI.65.3.1616-1618.1991

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Article

Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.

Journal of virology - 1 Mar 1991

Tangy F, McAllister A, Aubert C, Brahic M

Abstract excerpt

The DA strain of Theiler's virus persists in the central nervous systems of mice and causes chronic inflammation and demyelination. The GDVII strain, on the other hand, causes an acute encephalitis that kills the host in a matter of days. We constructed a series of recombinants between two infect...

Topics

Animals
Capsid
Capsid Proteins
Demyelinating Diseases
Genes, Viral
Mice
Mice, Inbred Strains
Phenotype
Picornaviridae
Recombination, Genetic
Restriction Mapping
Virulence

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